My long-time editor, Bret Stetka, MD, at Medscape.com, asked me to write about the effects of COVID-19 on the nervous system. There have been many recent reports of neurological symptoms associated with COVID-19, but the critical question remains whether the virus directly targets neurons or whether neurological symptoms result from indirect injury. Rabies virus, for example, directly infects the nervous system with 100% mortality. If SARS-CoV-2 does attack the brain directly